/* =========================================================================
   面向蛋白质定向进化的科学智能体 —— 浅色系界面
   配色：青绿 / 天蓝 / 琥珀 / 珊瑚（不含紫色）
   ========================================================================= */

:root {
  --teal:      #0E9F9B;
  --teal-dk:   #0A7F7C;
  --teal-lt:   #E4F4F3;
  --sky:       #3B93E0;
  --sky-lt:    #E6F1FC;
  --amber:     #E8A33D;
  --amber-lt:  #FBF0DC;
  --coral:     #E4694E;
  --coral-lt:  #FCEAE5;
  --green:     #4CA97B;
  --green-lt:  #E6F4ED;
  --rose:      #D96A84;

  --ink:       #1E2E3C;
  --slate:     #55697C;
  --muted:     #8DA0B3;
  --line:      #E4ECF3;
  --line-soft: #EFF4F8;

  --bg:        #F5F9FB;
  --card:      #FFFFFF;

  --shadow-sm: 0 1px 2px rgba(30,46,60,.04), 0 2px 8px rgba(30,46,60,.04);
  --shadow:    0 2px 4px rgba(30,46,60,.04), 0 10px 28px rgba(30,46,60,.07);
  --shadow-lg: 0 4px 10px rgba(30,46,60,.05), 0 22px 54px rgba(30,46,60,.11);

  --r-sm: 10px;
  --r:    16px;
  --r-lg: 22px;

  --ease: cubic-bezier(.22,.68,.32,1);
}

* { box-sizing: border-box; }

html { scroll-behavior: smooth; }

body {
  margin: 0;
  font-family: "Microsoft YaHei", "PingFang SC", "Segoe UI", system-ui, sans-serif;
  color: var(--ink);
  background: var(--bg);
  font-size: 15px;
  line-height: 1.68;
  -webkit-font-smoothing: antialiased;
}

/* 背景光晕 */
body::before {
  content: "";
  position: fixed;
  inset: 0;
  z-index: -1;
  background:
    radial-gradient(900px 480px at 8% -8%,  rgba(14,159,155,.13), transparent 62%),
    radial-gradient(760px 420px at 94% 2%,  rgba(59,147,224,.12), transparent 60%),
    radial-gradient(680px 420px at 62% 100%, rgba(232,163,61,.10), transparent 62%);
}

a { color: var(--teal-dk); text-decoration: none; }

/* ------------------------------------------------------------------ 左侧导航 */
:root { --side-w: 248px; }

.sidebar {
  position: fixed; left: 0; top: 0; bottom: 0; width: var(--side-w); z-index: 70;
  display: flex; flex-direction: column; gap: 6px;
  padding: 22px 16px 20px;
  background: rgba(255,255,255,.86);
  backdrop-filter: saturate(160%) blur(14px);
  border-right: 1px solid var(--line);
  overflow-y: auto; overscroll-behavior: contain;
  transition: transform .34s var(--ease);
}
.sidebar::-webkit-scrollbar { width: 6px; }
.sidebar::-webkit-scrollbar-thumb { background: var(--line); border-radius: 3px; }

.brand {
  display: flex; align-items: flex-start; gap: 11px;
  font-weight: 700; font-size: 14.5px; line-height: 1.35;
  padding: 6px 8px 16px; color: var(--ink);
  border-bottom: 1px solid var(--line-soft); margin-bottom: 12px;
}
.brand .dot {
  width: 36px; height: 36px; border-radius: 12px; flex: none;
  background: linear-gradient(135deg, var(--teal), var(--sky));
  display: grid; place-items: center; color: #fff; font-size: 16px;
  box-shadow: 0 6px 16px rgba(14,159,155,.34);
  animation: pulse-soft 4.5s var(--ease) infinite;
}
.brand small {
  display: block; font-weight: 400; font-size: 11px; color: var(--muted);
  letter-spacing: .2px; line-height: 1.5; margin-top: 5px;
}

@keyframes pulse-soft {
  0%,100% { transform: translateY(0) rotate(0deg); }
  50%     { transform: translateY(-3px) rotate(-4deg); }
}

.nav-label {
  font-size: 10.5px; font-weight: 700; letter-spacing: 1.2px;
  color: var(--muted); text-transform: uppercase;
  padding: 4px 10px 8px;
}

.nav { display: flex; flex-direction: column; gap: 3px; }
.nav a {
  position: relative; display: flex; align-items: center; gap: 11px;
  padding: 10px 12px; border-radius: 10px;
  color: var(--slate); font-size: 14px; font-weight: 500;
  transition: color .22s var(--ease), background .22s var(--ease), transform .22s var(--ease);
}
.nav a .ico {
  width: 22px; height: 22px; border-radius: 7px; flex: none;
  display: grid; place-items: center; font-size: 12px;
  background: var(--line-soft); color: var(--muted);
  transition: all .24s var(--ease);
}
.nav a::before {
  content: ""; position: absolute; left: -16px; top: 50%; transform: translateY(-50%) scaleY(0);
  width: 3px; height: 22px; border-radius: 0 3px 3px 0;
  background: linear-gradient(180deg, var(--teal), var(--sky));
  transition: transform .28s var(--ease);
}
.nav a:hover { color: var(--ink); background: var(--line-soft); transform: translateX(2px); }
.nav a:hover .ico { background: #fff; color: var(--teal); }
.nav a.active {
  color: var(--teal-dk); font-weight: 600;
  background: linear-gradient(90deg, var(--teal-lt), rgba(228,244,243,.25));
}
.nav a.active::before { transform: translateY(-50%) scaleY(1); }
.nav a.active .ico {
  background: linear-gradient(135deg, var(--teal), var(--sky)); color: #fff;
  box-shadow: 0 4px 10px rgba(14,159,155,.30);
}

.side-foot {
  margin-top: auto; padding-top: 18px; border-top: 1px solid var(--line-soft);
}
.side-kv {
  display: flex; justify-content: space-between; gap: 10px;
  padding: 5px 10px; font-size: 11.8px; color: var(--muted);
}
.side-kv b { color: var(--slate); font-weight: 600; text-align: right; }

.side-toggle {
  display: none; position: fixed; left: 14px; top: 14px; z-index: 90;
  width: 42px; height: 42px; border-radius: 12px; border: 1px solid var(--line);
  background: rgba(255,255,255,.94); color: var(--slate); font-size: 17px;
  cursor: pointer; box-shadow: var(--shadow-sm);
}
.side-scrim {
  display: none; position: fixed; inset: 0; z-index: 65;
  background: rgba(30,46,60,.26); opacity: 0; transition: opacity .3s var(--ease);
}

/* ------------------------------------------------------------------ 布局 */
.wrap {
  margin-left: var(--side-w);
  max-width: 1280px; padding: 34px 32px 60px;
}

@media (max-width: 980px) {
  .sidebar { transform: translateX(-100%); box-shadow: var(--shadow-lg); }
  body.side-open .sidebar { transform: none; }
  body.side-open .side-scrim { display: block; opacity: 1; }
  .side-toggle { display: block; }
  .wrap { margin-left: 0; padding: 70px 20px 60px; }
}

.section { margin-bottom: 42px; }
.section-head { display: flex; align-items: baseline; gap: 14px; margin-bottom: 18px; flex-wrap: wrap; }
.section-head h2 { margin: 0; font-size: 21px; letter-spacing: -.2px; }
.section-head p { margin: 0; color: var(--muted); font-size: 13.5px; }

.grid { display: grid; gap: 18px; }
.g2 { grid-template-columns: repeat(2, minmax(0,1fr)); }
.g3 { grid-template-columns: repeat(3, minmax(0,1fr)); }
.g4 { grid-template-columns: repeat(4, minmax(0,1fr)); }
.g23 { grid-template-columns: 1.4fr 1fr; }
@media (max-width: 1080px) { .g3, .g4, .g23 { grid-template-columns: repeat(2, minmax(0,1fr)); } }
@media (max-width: 720px)  { .g2, .g3, .g4, .g23 { grid-template-columns: 1fr; } }

/* ------------------------------------------------------------------ 卡片 */
.card {
  background: var(--card); border: 1px solid var(--line);
  border-radius: var(--r); padding: 22px;
  box-shadow: var(--shadow-sm);
  transition: transform .34s var(--ease), box-shadow .34s var(--ease), border-color .34s var(--ease);
}
.card.hover:hover { transform: translateY(-4px); box-shadow: var(--shadow); border-color: #D8E6EF; }
.card h3 { margin: 0 0 4px; font-size: 16px; }
.card .sub { color: var(--muted); font-size: 13px; margin-bottom: 14px; }

/* ------------------------------------------------------------------ Hero */
.hero {
  position: relative; overflow: hidden;
  border-radius: var(--r-lg); padding: 40px 42px;
  background: linear-gradient(135deg, #FFFFFF 0%, #F2FAFA 44%, #EDF5FD 100%);
  border: 1px solid var(--line);
  box-shadow: var(--shadow);
  margin-bottom: 30px;
}
.hero::after {
  content: ""; position: absolute; right: -90px; top: -110px;
  width: 380px; height: 380px; border-radius: 50%;
  background: radial-gradient(circle at 34% 34%, rgba(14,159,155,.20), rgba(59,147,224,.06) 62%, transparent 72%);
  animation: float 11s var(--ease) infinite;
}
@keyframes float {
  0%,100% { transform: translate(0,0) scale(1); }
  50%     { transform: translate(-22px, 22px) scale(1.07); }
}
.hero h1 { margin: 0 0 10px; font-size: 31px; letter-spacing: -.6px; line-height: 1.32; }
.hero .lede { color: var(--slate); max-width: 720px; font-size: 15px; }
.hero .tags { display: flex; flex-wrap: wrap; gap: 8px; margin-top: 20px; }

.pill {
  display: inline-flex; align-items: center; gap: 6px;
  padding: 5px 13px; border-radius: 999px;
  font-size: 12.5px; font-weight: 600; letter-spacing: .2px;
  background: var(--teal-lt); color: var(--teal-dk); border: 1px solid rgba(14,159,155,.20);
}
.pill.sky   { background: var(--sky-lt);   color: #24699F; border-color: rgba(59,147,224,.22); }
.pill.amber { background: var(--amber-lt); color: #A46D14; border-color: rgba(232,163,61,.26); }
.pill.coral { background: var(--coral-lt); color: #B1462C; border-color: rgba(228,105,78,.24); }
.pill.green { background: var(--green-lt); color: #2E7A54; border-color: rgba(76,169,123,.24); }
.pill.grey  { background: #EEF3F7;         color: var(--slate); border-color: var(--line); }

/* ------------------------------------------------------------------ 指标 */
.stat { position: relative; overflow: hidden; }
.stat::before {
  content: ""; position: absolute; left: 0; top: 0; bottom: 0; width: 3px;
  background: linear-gradient(180deg, var(--teal), var(--sky));
  transform: scaleY(0); transform-origin: top; transition: transform .6s var(--ease);
}
.stat.in::before { transform: scaleY(1); }
.stat .label { color: var(--muted); font-size: 12.5px; font-weight: 500; letter-spacing: .3px; }
.stat .value {
  font-size: 30px; font-weight: 700; letter-spacing: -1px; line-height: 1.22;
  font-variant-numeric: tabular-nums;
  background: linear-gradient(135deg, var(--teal-dk), var(--sky));
  -webkit-background-clip: text; background-clip: text; color: transparent;
}
.stat .value .unit { font-size: 15px; font-weight: 600; -webkit-text-fill-color: var(--muted); }
.stat .foot { color: var(--slate); font-size: 12.5px; }

/* ------------------------------------------------------------------ 表格 */
.table-wrap { overflow-x: auto; border-radius: var(--r-sm); border: 1px solid var(--line); }
table { width: 100%; border-collapse: collapse; font-size: 13.4px; background: #fff; }
thead th {
  position: sticky; top: 0;
  background: #F7FAFC; color: var(--slate); font-weight: 600;
  text-align: left; padding: 11px 13px; white-space: nowrap;
  border-bottom: 1px solid var(--line); font-size: 12.5px; letter-spacing: .2px;
}
tbody td { padding: 10px 13px; border-bottom: 1px solid var(--line-soft); vertical-align: top; }
tbody tr { transition: background .18s var(--ease); }
tbody tr:hover { background: #FAFCFE; }
tbody tr:last-child td { border-bottom: none; }
td.num, th.num { text-align: right; font-variant-numeric: tabular-nums; }
.mono { font-family: "Cascadia Mono", Consolas, "SF Mono", monospace; letter-spacing: .4px; }

/* 条形单元格 */
.bar-cell { position: relative; min-width: 110px; }
.bar-cell .bar {
  position: absolute; left: 0; top: 50%; transform: translateY(-50%);
  height: 20px; border-radius: 5px; opacity: .2;
  background: linear-gradient(90deg, var(--teal), var(--sky));
  width: 0; transition: width 1s var(--ease);
}
.bar-cell span { position: relative; }

/* ------------------------------------------------------------------ 序列 */
.seq {
  display: flex; flex-wrap: wrap; column-gap: 3px; row-gap: 24px;
  font-family: "Cascadia Mono", Consolas, monospace;
}
.seq .aa {
  position: relative;
  width: 25px; height: 30px; border-radius: 6px;
  display: grid; place-items: center; font-size: 12.5px; font-weight: 600;
  background: #F4F8FA; color: var(--slate); border: 1px solid var(--line-soft);
  transition: transform .2s var(--ease), box-shadow .2s var(--ease);
}
.seq .aa:hover { transform: translateY(-3px); box-shadow: var(--shadow-sm); z-index: 2; }
.seq .aa.hot {
  background: linear-gradient(135deg, var(--teal), var(--sky));
  color: #fff; border-color: transparent;
  box-shadow: 0 5px 14px rgba(14,159,155,.30);
}
.seq .aa.hot::after {
  content: attr(data-pos);
  position: absolute; top: 33px; left: 50%; transform: translateX(-50%);
  font-size: 10px; line-height: 1; color: var(--teal-dk); font-weight: 700;
}

/* ------------------------------------------------------------------ 流程 */
.pipeline { display: grid; gap: 12px; }
.pstep {
  display: grid; grid-template-columns: 42px 1fr; gap: 15px; align-items: start;
  padding: 16px 18px; border-radius: var(--r-sm);
  background: #FBFDFE; border: 1px solid var(--line);
  transition: transform .3s var(--ease), box-shadow .3s var(--ease), background .3s var(--ease);
}
.pstep:hover { transform: translateX(4px); box-shadow: var(--shadow-sm); background: #fff; }
.pstep .idx {
  width: 42px; height: 42px; border-radius: 13px; display: grid; place-items: center;
  font-weight: 700; font-size: 15px; color: #fff;
  background: linear-gradient(135deg, var(--teal), var(--sky));
  box-shadow: 0 6px 15px rgba(14,159,155,.26);
}
.pstep:nth-child(2) .idx { background: linear-gradient(135deg, var(--sky), #5AA9E6); box-shadow: 0 6px 15px rgba(59,147,224,.26); }
.pstep:nth-child(3) .idx { background: linear-gradient(135deg, var(--amber), #EFB962); box-shadow: 0 6px 15px rgba(232,163,61,.26); }
.pstep:nth-child(4) .idx { background: linear-gradient(135deg, var(--green), #6BC094); box-shadow: 0 6px 15px rgba(76,169,123,.26); }
.pstep:nth-child(5) .idx { background: linear-gradient(135deg, var(--coral), #EE8A72); box-shadow: 0 6px 15px rgba(228,105,78,.26); }
.pstep h4 { margin: 0 0 3px; font-size: 15px; }
.pstep p  { margin: 0; color: var(--slate); font-size: 13.4px; }

/* ------------------------------------------------------------------ 折叠 */
details.acc {
  border: 1px solid var(--line); border-radius: var(--r-sm);
  background: #fff; margin-bottom: 10px; overflow: hidden;
  transition: box-shadow .26s var(--ease), border-color .26s var(--ease);
}
details.acc[open] { box-shadow: var(--shadow-sm); border-color: #D8E6EF; }
details.acc > summary {
  cursor: pointer; padding: 13px 17px; font-weight: 600; font-size: 14px;
  list-style: none; display: flex; align-items: center; gap: 10px;
  transition: background .2s var(--ease);
}
details.acc > summary:hover { background: #F8FBFC; }
details.acc > summary::-webkit-details-marker { display: none; }
details.acc > summary::before {
  content: "›"; font-size: 19px; color: var(--muted); line-height: 1;
  transition: transform .28s var(--ease); display: inline-block;
}
details.acc[open] > summary::before { transform: rotate(90deg); color: var(--teal); }
details.acc .body { padding: 2px 17px 17px; border-top: 1px solid var(--line-soft); }

pre.code {
  margin: 0; padding: 15px 17px; border-radius: var(--r-sm);
  background: #F7FAFC; border: 1px solid var(--line);
  font-family: "Cascadia Mono", Consolas, monospace; font-size: 12.3px;
  line-height: 1.66; color: #33485C; white-space: pre-wrap; word-break: break-word;
  max-height: 430px; overflow: auto;
}
pre.code.sys { background: var(--teal-lt); border-color: rgba(14,159,155,.20); }
pre.code.out { background: var(--amber-lt); border-color: rgba(232,163,61,.24); }
/* 推理型模型返回的思维链：与正式输出区分，淡蓝底 + 斜体 */
pre.code.think {
  background: var(--sky-lt);
  border-color: rgba(59,147,224,.22);
  font-style: italic;
  max-height: 360px;
  overflow: auto;
}

/* ------------------------------------------------------------------ 控件 */
.controls { display: flex; flex-wrap: wrap; gap: 14px; align-items: flex-end; }
.field label { display: block; font-size: 12.5px; color: var(--muted); margin-bottom: 6px; font-weight: 500; }
.field select, .field input[type=number] {
  padding: 9px 13px; border-radius: 10px; border: 1px solid var(--line);
  background: #fff; font-family: inherit; font-size: 14px; color: var(--ink);
  transition: border-color .2s var(--ease), box-shadow .2s var(--ease);
}
.field select:focus, .field input:focus {
  outline: none; border-color: var(--teal); box-shadow: 0 0 0 3px rgba(14,159,155,.14);
}

/* 序列输入 */
.seq-input {
  width: 100%; padding: 13px 15px; border-radius: 12px;
  border: 1px solid var(--line); background: #FBFDFE;
  font-family: "Cascadia Mono", Consolas, "SF Mono", monospace;
  font-size: 12.8px; line-height: 1.66; color: var(--ink);
  resize: vertical; min-height: 78px;
  transition: border-color .22s var(--ease), box-shadow .22s var(--ease), background .22s var(--ease);
}
.seq-input:focus {
  outline: none; background: #fff; border-color: var(--teal);
  box-shadow: 0 0 0 3px rgba(14,159,155,.13);
}
.seq-input::placeholder { color: var(--muted); font-size: 12.2px; }

.chips { display: flex; flex-wrap: wrap; gap: 7px; margin-top: 10px; }
.chips button {
  border: 1px solid var(--line); background: #fff; cursor: pointer;
  font-family: inherit; font-size: 12.4px; color: var(--slate);
  padding: 5px 13px; border-radius: 999px;
  transition: all .22s var(--ease);
}
.chips button:hover {
  border-color: var(--teal); color: var(--teal-dk);
  background: var(--teal-lt); transform: translateY(-1px);
}

.seq-status {
  display: flex; flex-wrap: wrap; align-items: center; gap: 8px;
  margin-top: 12px; font-size: 12.8px; min-height: 22px;
  color: var(--slate);
  opacity: 0; transform: translateY(-4px);
  animation: fade-in .34s var(--ease) forwards;
}
.seq-status.ok      { color: #2A6B4A; }
.seq-status.bad     { color: #B1462C; }
.seq-status.pending { color: var(--muted); }
@keyframes fade-in { to { opacity: 1; transform: none; } }

.btn {
  display: inline-flex; align-items: center; gap: 9px;
  padding: 11px 24px; border-radius: 11px; border: none; cursor: pointer;
  font-family: inherit; font-size: 14.5px; font-weight: 600; color: #fff;
  background: linear-gradient(135deg, var(--teal), var(--sky));
  box-shadow: 0 6px 18px rgba(14,159,155,.30);
  transition: transform .2s var(--ease), box-shadow .2s var(--ease), filter .2s var(--ease);
}
.btn:hover { transform: translateY(-2px); box-shadow: 0 10px 26px rgba(14,159,155,.36); }
.btn:active { transform: translateY(0); }
.btn:disabled { filter: grayscale(.55) opacity(.65); cursor: not-allowed; transform: none; }
.btn .spin {
  width: 15px; height: 15px; border-radius: 50%; display: none;
  border: 2px solid rgba(255,255,255,.4); border-top-color: #fff;
  animation: spin .75s linear infinite;
}
.btn.loading .spin { display: block; }
@keyframes spin { to { transform: rotate(360deg); } }

.toggle { display: inline-flex; background: #EEF3F7; border-radius: 11px; padding: 4px; gap: 4px; }
.toggle button {
  border: none; background: transparent; cursor: pointer; font-family: inherit;
  padding: 8px 17px; border-radius: 8px; font-size: 13.5px; font-weight: 600; color: var(--slate);
  transition: all .24s var(--ease);
}
.toggle button.on { background: #fff; color: var(--teal-dk); box-shadow: var(--shadow-sm); }

/* ------------------------------------------------------------------ 徽标 */
.tag {
  display: inline-block; padding: 2px 9px; border-radius: 6px;
  font-size: 11.5px; font-weight: 600; letter-spacing: .2px;
  background: #EEF3F7; color: var(--slate);
}
.tag.ok   { background: var(--green-lt); color: #2E7A54; }
.tag.warn { background: var(--amber-lt); color: #A46D14; }
.tag.bad  { background: var(--coral-lt); color: #B1462C; }
.tag.info { background: var(--sky-lt);   color: #24699F; }
.tag.teal { background: var(--teal-lt);  color: var(--teal-dk); }

/* ------------------------------------------------------------------ 图表 */
.chart-box { position: relative; height: 300px; }
.chart-box.tall { height: 360px; }

.figure {
  border-radius: var(--r); overflow: hidden; border: 1px solid var(--line);
  background: #fff; box-shadow: var(--shadow-sm);
  transition: transform .34s var(--ease), box-shadow .34s var(--ease);
}
.figure:hover { transform: translateY(-4px); box-shadow: var(--shadow); }
.figure img { width: 100%; display: block; }
.figure .cap { padding: 14px 18px; border-top: 1px solid var(--line-soft); }
.figure .cap h4 { margin: 0 0 3px; font-size: 14.5px; }
.figure .cap p { margin: 0; color: var(--muted); font-size: 12.8px; }

/* ------------------------------------------------------------------ 结构位点 */
.poscard { border-left: 3px solid var(--teal); }
.poscard.risk { border-left-color: var(--coral); }
.poscard.key  { border-left-color: var(--amber); }
.poscard .code {
  display: inline-flex; align-items: center; justify-content: center;
  min-width: 52px; height: 34px; padding: 0 10px; border-radius: 9px;
  font-family: "Cascadia Mono", Consolas, monospace; font-weight: 700; font-size: 15px;
  background: var(--teal-lt); color: var(--teal-dk);
}
.poscard.risk .code { background: var(--coral-lt); color: #B1462C; }
.poscard.key  .code { background: var(--amber-lt); color: #A46D14; }

/* ------------------------------------------------------------------ 提示条 */
.note {
  display: flex; gap: 12px; padding: 14px 17px; border-radius: var(--r-sm);
  background: var(--sky-lt); border: 1px solid rgba(59,147,224,.20);
  color: #2A5B80; font-size: 13.5px; line-height: 1.62;
}
.note.warn  { background: var(--amber-lt); border-color: rgba(232,163,61,.26); color: #8A5C10; }
.note.ok    { background: var(--green-lt); border-color: rgba(76,169,123,.24); color: #2A6B4A; }
.note b { color: inherit; }

/* ------------------------------------------------------------------ 入场动画 */
.reveal { opacity: 0; transform: translateY(16px); transition: opacity .62s var(--ease), transform .62s var(--ease); }
.reveal.in { opacity: 1; transform: none; }

/* ------------------------------------------------------------------ 骨架屏 */
.skeleton {
  border-radius: var(--r-sm); height: 15px; margin: 9px 0;
  background: linear-gradient(90deg, #EEF3F7 25%, #F7FAFC 50%, #EEF3F7 75%);
  background-size: 400% 100%; animation: shimmer 1.35s ease-in-out infinite;
}
@keyframes shimmer { 0% { background-position: 100% 0; } 100% { background-position: 0 0; } }

footer {
  border-top: 1px solid var(--line); margin-top: 40px;
  padding: 24px 0 10px; color: var(--muted); font-size: 12.6px;
}
footer .inner { display: flex; gap: 20px; flex-wrap: wrap; }